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Prof Hill told The Independent earlier this year that he believed his treatment could help to potentially eradicate malaria within 20 years It belongs to the class called proton pump inhibitors, which means that its mechanism of action is based on blocking the secretion of the stomach acid. For more than 170 years, we have worked to make a difference for all who rely on us. If the Aciphex has not imporved symptoms in 7 months, it is past time to try something else or to increase the dosage if possible. Since all the new studues came out about it being so bad long term, I decided to try and get off it. Mission & History; Strategic Plan; Keep America Beautiful Positions; How Donations are Used; Annual Reports; Our Team. When is the best time to take Aciphex? AcipHex is for short-term use only, usually 4 to 8 weeks. How long should I take Aciphex? ACIPHEX® has a well-established safety profile. The most common side effect possibly related to ACIPHEX® is headache. 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