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Bactrim is an antibiotic medicine that contains two antibiotics, sulfamethoxazole and trimethoprim Answers. Get in the habit of taking it with the same meal every day. It shouldn't be taken with calcium and vitamin E. Biktarvy is taken by itself (not with other HIV-1 medicines) to treat HIV-1 infection. It is more important that the Bactrim be taken about 12 hours apart, and it is not necessary to schedule meals to accommodate that schedule Oct 31, · Take with or without food. While the documentation with my Lasix says it can be taken with or without food, I have found that the drug is much more effective taken on an empty stomach. Taking it with food slows down how fast your body absorbs the medicine. Most water-soluble vitamins can be taken on an empty stomach if you can tolerate it Last Updated 3/5/2020 Treatment Some beta blockers must be taken with food, while others should not be taken with food. If it bothers your stomach, try taking it with food. 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